Patient Referral
For HCPs / Patient Referral
Treatment with CHEMOSAT has been shown to slow down and, in some cases, halt the progression of hepatic tumours in patients with metastatic uveal melanoma.
Recent UK guidelines and German S3 guidelines have recommended the use of liver directed therapy. 1,2
Delcath have a number of expert CHEMOSAT centres located throughout Europe. Referring a patient is easy, just follow the instructions below.
Download the Referral Form
Contact a CHEMOSAT referral expert
Referral Pathway • Unresectable Hepatic Dominant Uveal Melanoma*3-6
In line with UK & German S3 guidelines, patients presenting with hepatic dominant disease where re-section is not suitable should be considered for liver-directed therapy.
01
Assess Eligibility 7
02
Referring
Oncologist
Clinical Assessment
02/B
Identify referral site in consultation with patient
04
Assessment by
Expert CHEMOSAT
Team
05
CHEMOSAT Treatment every 6-8 weeks
06
Post Treatment
Assessment
*For illustrative purposes only, tests and timelines may vary depending on the hospital and individual clinical needs. Subject to individual centre experience.
Patient Timelines and Touchpoints**7
REFERRAL
Location:
CHEMOSAT Centre / Local Oncology Unit
ASSESSMENT
Location:
CHEMOSAT Centre
TREATMENT
Location:
CHEMOSAT Centre
RE-ASSESSMENT
Location:
CHEMOSAT Centre / Local Oncology Unit / GP
FOLLOW UP
Location:
CHEMOSAT Centre / Local Oncology Unit / GP
** Tests and timelines may vary depending on hospital and individual clinical needs. Subject to individual centre experience.
Oncologist
A medical oncologist will usually be responsible for ensuring that CHEMOSAT is the right treatment approach for their patient. They are experienced in the monitoring of toxicities of chemotherapy and are responsible for the complete medical management of the patient, including, but not limited to, pre- and postoperative care. They may also be responsible for monitoring the patient during the immediate post-procedure period.
Intensivist/critical care specialist
A qualified intensivist, or appropriately qualified critical care specialist, is responsible for providing medical management of the patient in the immediate post-procedure period, during which the patient is in the intensive care unit or step down unit.
lnterventional radiologist
A qualified interventional radiologist with the knowledge, skills, experience, and hospital privileges required to perform advanced vascular interventional procedures.
Nurse
A qualified chemotherapy healthcare professional certified by the site to deliver chemotherapy, such as Interventional Radiology Technician or Registered Nurse.
Perfusionist
A qualified perfusionist is required to establish, monitor, and control the extracorporeal pump and veno-venous bypass circuit.
Anaesthesiologist
A qualified anaesthetist (anaesthesiologist) and/or nurse anaesthetist responsible for the management of sedation, analgesia, respiratory and cardiovascular support.
Pharmacist
A qualified pharmacist, on call during the procedure, to reconstitute the chemotherapeutic agent (melphalan hydrochloride), using national and local safety guidelines. The pharmacist should be aware of the rapid preparation time required for the preparation and administration of melphalan for use with CHEMOSAT.
Assess Eligibility 7
*Patients with 50% or greater tumour burden of the liver on imaging should have a laparoscopy and normal liver biopsied for both visual inspection of liver parenchyma and histological examination of the liver to rule out hepatocellular dysfunction at a subclinical level
Clinical Assessment
Assessment by Expert CHEMOSAT Team
Post Treatment Assessment
Week 1 - blood tests
Week 2 - blood tests
Week 3 - blood tests
Week 6-8 - post treatment MRI to assess response
Thank you for your interest in CHEMOSAT.
The following pages are exclusively reserved for health care professionals licensed in the European Union, the United Kingdom, Switzerland, Norway, Iceland, Turkey & Liechtenstein where the product has been CE marked.
If you are located outside of these regions, please click here (www.delcath.com)
Information provided on this site is not intended to be professional medical advice. Product Instructions for Use (IFU) should be consulted before use of the product.
I UNDERSTAND AND AGREE TO THE STATEMENT ABOVECHEMOSAT: A 3 Step Process
Czech Republic
Publication Date | Document and Revision number | Language |
---|---|---|
26-JUL-2023 | 120056 Rev E | Czech • Download |
26-JUL-2023 | 120056 Rev E | English • Download |
21-APR-2022 | 120056 Rev D | Czech • Download |
21-APR-2022 | 120056 Rev D | English • Download |
08-MAR-2021 | 120056 Rev C | Czech • Download |
08-MAR-2021 | 120056 Rev C | English • Download |
France
Publication Date | Document and Revision number | Language |
---|---|---|
22-JAN-2024 | 120057 Rev F | French • Download |
22-JAN-2024 | 120057 Rev F | English • Download |
26-JUL-2023 | 120057 Rev E | French • Download |
26-JUL-2023 | 120057 Rev E | English • Download |
21-APR-2022 | 120057 Rev D | French • Download |
21-APR-2022 | 120057 Rev D | English • Download |
08-MAR-2021 | 120057 Rev C | French • Download |
08-MAR-2021 | 120057 Rev C | English • Download |
Germany
Publication Date | Document and Revision number | Language |
---|---|---|
26-JUL-2023 | 120055 Rev F | German • Download |
26-JUL-2023 | 120054 Rev F | English • Download |
21-APR-2022 | 120055 Rev E | German • Download |
04-APR-2022 | 120054 Rev E | English • Download |
08-MAR-2021 | 120055 Rev D | German • Download |
08-MAR-2021 | 120054 Rev D | English • Download |
Italy
Publication Date | Document and Revision number | Language |
---|---|---|
26-JUL-2023 | 120056 Rev E | Italian • Download |
26-JUL-2023 | 120056 Rev E | English • Download |
21-APR-2022 | 120056 Rev D | Italian • Download |
21-APR-2022 | 120056 Rev D | English • Download |
08-MAR-2021 | 120056 Rev C | Italian • Download |
08-MAR-2021 | 120056 Rev C | English • Download |
The Netherlands
Publication Date | Document and Revision number | Language |
---|---|---|
26-JUL-2023 | 120055 Rev F | Dutch • Download |
26-JUL-2023 | 120054 Rev F | English • Download |
21-APR-2022 | 120055 Rev E | Dutch • Download |
04-APR-2022 | 120054 Rev E | English • Download |
08-MAR-2021 | 120055 Rev D | Dutch • Download |
08-MAR-2021 | 120054 Rev D | English • Download |
Portugal
Publication Date | Document and Revision number | Language |
---|---|---|
26-JUL-2023 | 120056 Rev E | Portuguese • Download |
26-JUL-2023 | 120056 Rev E | English • Download |
21-APR-2022 | 120056 Rev D | Portuguese • Download |
21-APR-2022 | 120056 Rev D | English • Download |
08-MAR-2021 | 120056 Rev C | Portuguese • Download |
08-MAR-2021 | 120056 Rev C | English • Download |
Spain
Publication Date | Document and Revision number | Language |
---|---|---|
22-JAN-2024 | 120057 Rev F | Spanish • Download |
22-JAN-2024 | 120057 Rev F | English • Download |
26-JUL-2023 | 120057 Rev E | Spanish • Download |
26-JUL-2023 | 120057 Rev E | English • Download |
21-APR-2022 | 120057 Rev D | Spanish • Download |
21-APR-2022 | 120057 Rev D | English • Download |
08-MAR-2021 | 120057 Rev C | Spanish • Download |
08-MAR-2021 | 120057 Rev C | English • Download |
References
References
References
References
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