CHEMOSAT: A 3 Step Process
Catheters are inserted percutaneously through femoral arteries to isolate hepatic vascular supply from the rest of the body.
30 minute intra-arterial administration of the chemotherapeutic agent melphalan through the hepatic artery.
Extracorporeal filtration of the hepatic venous blood lowers the concentration of the chemotherapeutic agent in the blood before returning it to the systemic venous circulation.
Total treatment time is 2-3 hours*
* Treatment time may vary depending on individual centre experience.
CHEMOSAT Treating Team3
The procedure typically takes approximately 2-3 hours* to complete: this time will include transferring the patient to the IR suite, anaesthetising the patient, insertion of catheters, as well as delivery and filtration of the chemotherapeutic agent melphalan.
A core multidisciplinary team including a medical oncologist, interventional radiologist, anaesthetist, perfusionist, pharmacist and a nurse will assist in the treatment.
Click on the links below to find out more about each individual's role pre, peri and post procedure.
Intensivist/critical care specialist
* Treatment time may vary depending on clinical experience and patient factors.
Hear from our experts and their role in the procedure
Multiple prospective & retrospective studies have shown efficacy and safety across various endpoints in metastatic uveal melanoma. The usage of CHEMOSAT in the combination setting is also being investigated in the CHOPIN study.
CHEMOSAT procedures performed
CHEMOSAT in combination with IO in mUM. Additional tumour types such as ICC & CRC** are under consideration
**IO (immunotherapy), ICC (intrahepatic cholangiocarcinoma) & CRC (colorectal cancer)